A more recent trial conducted in Europe attempted to finally demystify the comparisons between NSAIDs and selective COX-2 inhibitors. Researchers pooled data from several previous clinical trials to compare the incidence of serious gastrointestinal and cardiovascular events. Researchers found on a whole, the COX-2 inhinitors caused less serious gastrointestinal effects without causing a significant increase in heart attacks and strokes. This was for five different coxibs, namely celecoxib, valdecoxib, etoricoxib, rofecoxib and lumiracoxib. Surprisingly the former two agents actually caused less cardiovascular events when directly compared to traditional NSAID treatments.
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