Topical non-steroidal anti-inflammatory drugs a review of their use and toxicity

Articular damage in the foot in RA is the result of synovitis compounded by the considerable mechanical stresses occurring in this weightbearing structure. When un- or undertreated, synovitis combined with mechanical stress in the subtalar and talonavicular joints results in characteristic irreversible structural changes such as flattening of the medial longitudinal arch, valgus deformity of the calcaneus, and tibialis posterior dysfunction. 8,13,14 With better disease-modifying anti-rheumatic drug (DMARD) therapy and earlier intervention, this classic ‘rheumatoid foot’ is likely to become less common, although it must be remembered that not all patients do well, even on biologics. Furthermore, in a small proportion of cases our experience is that good disease control elsewhere in the body is not matched by equally good disease control in the weightbearing joints of the feet.

Corneal abrasions are also a common and recurrent feature in people who suffer specific types of corneal dystrophy, such as lattice corneal dystrophy. Lattice dystrophy gets its name from an accumulation of amyloid deposits, or abnormal protein fibers, throughout the middle and anterior stroma. During an eye examination, the doctor sees these deposits in the stroma as clear, comma-shaped overlapping dots and branching filaments, creating a lattice effect. Over time, the lattice lines will grow opaque and involve more of the stroma. They will also gradually converge, giving the cornea a cloudiness that may also reduce vision. In some people, these abnormal protein fibers can accumulate under the cornea's outer layer—the epithelium. This can cause erosion of the epithelium. This condition is known as recurrent epithelial erosion. These erosions: (1) Alter the cornea's normal curvature, resulting in temporary vision problems; and (2) Expose the nerves that line the cornea, causing severe pain. Even the involuntary act of blinking can be painful.

Что было изучено в этом обзоре?
Повреждение роговицы это "царапина" на роговице глаза. Роговица - прозрачное окно, располагающееся перед радужкой, цветной частью глаза. Роговица важна как для зрения, так и для защиты глаза. Повреждение роговицы вызывает сильную боль и дискомфорт. Травматическое повреждение роговицы - повреждение роговицы вследствие травмы, например, удара в глаз, или вследствие попадания под веко чего-то вроде грязи или песка, которые царапают роговицу.

Topical non-steroidal anti-inflammatory drugs a review of their use and toxicity

topical non-steroidal anti-inflammatory drugs a review of their use and toxicity

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