Tamoxifen whilst on steroids

During chemotherapy I experienced hot flushes and sweats especially living in North Queensland. I would sit in front of a fan in an air-conditioned (20 degrees) room and the sweating and hot flushes still kept coming. As the years pasted and I eased into Tamoxifen I started to notice that my flushes gradually lessened and now after four years I no longer experience them. From when my cancer was diagnosed my menstrual periods stopped. I was told my periods may become irregular, lighter or sometimes stop altogether. Mine stopped altogether. Three years into Tamoxifen my periods returned which for me is a sign of hope that I should be able to conceive naturally (when the time comes).

It was once commonly used during PCT in the belief it will aid testosterone restoration, however this is flawed due to its mechanism of action. The drug mimics the effects of LH in the body, stimulating the Leydig cells to produce testosterone in the testes . This can be fruitful in rectify existing, or avoiding testicular atrophy on cycle. It will not aid the process of recovery in the post cycle phase however, as the drug will bring about heightened oestrogen levels due to the greater aromatising of the testosterone being produced in the testes , thus bringing about greater inhibition of the HPTA .

Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer in high risk women. To date studies have not included enough BRCA1 or BRCA2 mutation carriers to determine if it is effective for primary prevention in this population. Tamoxifen use is associated with a reduction in contralateral breast cancer risk by 67% in BRCA2 mutation carriers with breast cancer; such benefit is stronger if ovaries are still intact . r In view of the potential side effects associated with tamoxifen/raloxifene, risk-reducing medications should be discussed with an experienced medical professional to determine the relevant risks and benefits in an individual mutation carrier. See Cancer Australia Risk-reducing medication resource

I found this article fascinating, especially as I have already had a conversation with my doctor regarding the risk of developing breast cancer whilst using HRT – I am post-menopausal, but had 4 miscarriages before my son was born, and when my hormones were tracked, they revealed a 24-day cycle where progesterone, follicle-stimulating hormone and luteinising hormone were deficient, whilst oestrogen was relatively normal. The question I asked my doctor was, if you were exposed to oestrogen more often because of a short cycle, does that put you at higher risk of breast cancer? He said it was a very good question, but couldn’t answer it. I don’t know if any of this sheds any light on the problems you’re investigating, but I have wondered about this so often that I felt it was important for me to send this comment.

Tamoxifen whilst on steroids

tamoxifen whilst on steroids

I found this article fascinating, especially as I have already had a conversation with my doctor regarding the risk of developing breast cancer whilst using HRT – I am post-menopausal, but had 4 miscarriages before my son was born, and when my hormones were tracked, they revealed a 24-day cycle where progesterone, follicle-stimulating hormone and luteinising hormone were deficient, whilst oestrogen was relatively normal. The question I asked my doctor was, if you were exposed to oestrogen more often because of a short cycle, does that put you at higher risk of breast cancer? He said it was a very good question, but couldn’t answer it. I don’t know if any of this sheds any light on the problems you’re investigating, but I have wondered about this so often that I felt it was important for me to send this comment.

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