Signal transduction mechanism for estrogen a steroid hormone

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One of the most important functions of cell signaling is to control and maintain normal physiological balance within the body. Activation of different signaling pathways leads to diverse physiological responses, such as cell proliferation, death, differentiation, and metabolism. In the last few years signal transduction therapy has become one of the most important areas of modern drug research. In a healthy organism, the processes of cellular growth and differentiation are tightly controlled, but in the pathological state, are uncoupled in such a way as to result in further damage-causing signals, or the growth of the malfunctioning cells. Proliferation of damaged or malfunctioning cells is often a key factor in the generation of disorders such as cancer , infectious diseases, inflammation, arteriosclerosis, arthritis , and neurodegenerative diseases .

Essentially every biochemical process presented in the remainder of this book either is a component of a signal-transduction pathway or can be affected by one. As we shall see, the use of protein modules in various combinations is a clear, even dominant, theme in the construction of signal-transduction proteins. Signal-transduction proteins have evolved by the addition of such ancillary modules to core domains to facilitate interactions with other proteins or cell membranes. By controlling which proteins interact with one another, these modules play important roles in determining the wiring diagrams for signal-transduction circuits.

Signal transduction mechanism for estrogen a steroid hormone

signal transduction mechanism for estrogen a steroid hormone

Essentially every biochemical process presented in the remainder of this book either is a component of a signal-transduction pathway or can be affected by one. As we shall see, the use of protein modules in various combinations is a clear, even dominant, theme in the construction of signal-transduction proteins. Signal-transduction proteins have evolved by the addition of such ancillary modules to core domains to facilitate interactions with other proteins or cell membranes. By controlling which proteins interact with one another, these modules play important roles in determining the wiring diagrams for signal-transduction circuits.

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