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In conjunction with the corporate name change, we will also be changing our NASDAQ ticker symbol from ISIS to IONS. The new ticker symbol will become effective at the open of the market on December 22, 2015. In addition, we will have a new website address: , a new email domain: @ and a new Twitter account: @ionispharma. Visitors to our old website will be redirected to our new site and email sent to our old email addresses will still be delivered correctly. Our company address and phone numbers will not change.

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