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In the 1980s, thanks to iodophobia, iodine was replaced with bromine in the bread-making process. 31 Bromide is a goitrogen and interferes with iodide utilization by the thyroid gland, 32-34 and possibly by the mammary gland also. 35 Iodine has an anticarcinogenic effect on the breast. 30 The last national nutritional survey showed a trend of decreasing iodine intake by the US population. 30, 31 Currently 15% of the US adult female population excreted in their urine less than mg iodide/L, a level classified by the World Health Organization (WHO) as iodine deficiency. One must keep in mind that the amounts of daily intake of iodine set by the WHO were recommended with the goal of preventing simple goiter and stupidity (cretinism), not sufficiency of the whole human body for iodine, an amount we estimated to be 100-fold higher than the recommended daily intake. 30 Concurrent with the decreased intake of iodine/iodide and increased intake of bromine in the US population, a trend of increasing prevalence of cancers of the mammary and thyroid glands was reported. 30

Possible effects include cardiomyopathy; increased LDL and decreased HDL cholesterol; increased platelet aggregation; increased blood pressure; gynecomastia (male development of large mammary glands); acne; hair loss; hirsutism (excess body hair) in females; cholestasis (a liver disorder); liver cancer; fatty liver; testicular atrophy; erectile dysfunction; prostate disease; breast atropy (females); virilization in females; menstrual changes; aggression, anxiety, psychosis (“’roid rage”), and depression. 1,13,17-19 Androstenedione may, however, raise serum testosterone levels in women. 19

Possible increased risk of developing malignancies of the skin and lymphoproliferative disorders in patients receiving cyclosporine to treat psoriasis. 431 Evaluate such patients thoroughly before initiating cyclosporine therapy, as well as during the treatment course, for the presence of malignancies; consider that psoriatic plaques may obscure malignant lesions. 431 Avoid concomitant therapy with methotrexate or other immunosuppressive agents, coal tar, PUVA, UVB, or other radiation, due to potential for excessive immunosuppression and increased risk of malignancies. 431 Limit exposure to sunlight or other UV light during cyclosporine therapy. 476 477 478

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