Paracetamol (acetaminophen) and NSAIDs , such as ibuprofen , may be used to reduce fever and pain. Prednisone , a corticosteroid , while used to try to reduce throat pain or enlarged tonsils , remains controversial due to the lack of evidence that it is effective and the potential for side effects.   Intravenous corticosteroids , usually hydrocortisone or dexamethasone , are not recommended for routine use but may be useful if there is a risk of airway obstruction, a very low platelet count , or hemolytic anemia .  
Infectious mononucleosis , or " mono " as it is commonly referred to, is a viral illness that causes extreme fatigue , fever , muscle aches, swollen lymph nodes , and sore throat . It is sometimes called “the kissing disease” because it spreads easily through saliva. The Epstein-Barr virus (EBV) causes most cases of mono, although other viruses may cause the illness. Severe cases of mono may cause inflammation of the liver or spleen. If the spleen is enlarged, it is important to avoid vigorous physical activity and contact sports to reduce the risk of spleen rupture.