Cases of severe hepatotoxicity, including hepatic necrosis, life-threatening hepatic failure, and fatal events, have been reported with CIPRO XR. Acute liver injury is rapid in onset (range days), and is often associated with hypersensitivity. The pattern of injury can be hepatocellular, cholestatic or mixed. Most patients with fatal outcomes were older than 55 years old. In the event of any signs and symptoms of hepatitis (such as anorexia , jaundice, dark urine, pruritus , or tender abdomen), discontinue treatment immediately.
Adults : Between-group comparisons for pooled placebo-controlled trials revealed no statistically significant SEROQUEL/placebo differences in the proportions of patients experiencing potentially important changes in ECG parameters, including QT, QTc, and PR intervals. However, the proportions of patients meeting the criteria for tachycardia were compared in four 3- to 6-week placebo-controlled clinical trials for the treatment of schizophrenia revealing a 1% (4/399) incidence for SEROQUEL compared to % (1/156) incidence for placebo. In acute (monotherapy) bipolar mania trials the proportions of patients meeting the criteria for tachycardia was % (1/192) for SEROQUEL compared to 0% (0/178) incidence for placebo. In acute bipolar mania (adjunct) trials the proportions of patients meeting the same criteria was % (1/166) for SEROQUEL compared to 0% (0/171) incidence for placebo. In bipolar depression trials, no patients had heart rate increases to > 120 beats per minute. SEROQUEL use was associated with a mean increase in heart rate, assessed by ECG, of 7 beats per minute compared to a mean increase of 1 beat per minute among placebo patients. This slight tendency to tachycardia in adults may be related to SEROQUEL's potential for inducing orthostatic changes [see WARNINGS AND PRECAUTIONS ].
Hello. I’m curious what you mean that you still suffer from the clot you had years ago. It didn’t dissolve with the Nattokinase and Serrapeptace? Do you suffer from the medicine they had you on? This concerns me because I’m trying to decide if I should take the xarelto my doctor prescribed for the small clot I got from a vein surgery I recently had or if I should stay on the Nattokinase and Serrapeptace I started two days ago. I felt nauseous and scared this morning because my dr told me I’ll be fine as long as I take xarelto. I also might have taken too much. 3times yesterday and also Vit. E, fish oil and aspirin. I might have overdone it. Your opinion would be appreciated.