The formation of CYP450 enzymes may be suppressed by increased levels of cytokines (., TNFα) during chronic inflammation. Therefore, it is expected that for a molecule that antagonizes cytokine activity, such as golimumab, the formation of CYP450 enzymes could be normalized. Upon initiation or discontinuation of SIMPONI in patients being treated with CYP450 substrates with a narrow therapeutic index, monitoring of the effect (., warfarin) or drug concentration (., cyclosporine or theophylline) is recommended and the individual dose of the drug product may be adjusted as needed.
Alfa Intes is one of the Italian leading groups committed in the manufacturing and marketing of eye health products ranging from ophtalmic pharmaceuticals and medical devices to nutraceuticals. Alfa Intes represents a consolidated reality within the Italian market with more than 60 years of experience driven by the same ambition: becoming the unique point of reference for every user in the ophtalmological market. Recently Alfa Intes is expanding is network pointing on the exporting of the products belonging to its portfolio.
Our goal is pointing to the future by providing innovative products within the highest quality standards required always at the service of our final customers.